Key features and details
- Potent, selective, cell-permeable protein kinase C (PKC) inhibitor
- CAS Number: 145333-02-4
- Purity: > 98%
- Soluble in DMSO to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameBisindolylmaleimide XI hydrochloride, PKC inhibitor
DescriptionPotent, selective, cell-permeable protein kinase C (PKC) inhibitor
- BIM XI
- Ro 32-0432
permeable protein kinase C (PKC) inhibitor that displays 10- fold greater selectivity for PKCα (IC50 = 9 nM) and 4- fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+- independent PKCε (IC50 = 108 nM). Enhances cardiac contractility and protection from heart failure. Prevents T- cell activation and proliferation (IC50s ranging from 30- 150 nM) associated with chronic inflammatory responses in vivo. Also inhibits GRK2, GRK5, and GRK6 (IC50 values are 29, 3.6, and 16 µM, respectively).
Chemical name3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 10 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab143783 has not yet been referenced specifically in any publications.