Bisphenol A, Endocrine disrupting agent (ab144711)

Overview

  • Product name

    Bisphenol A, Endocrine disrupting agent
  • Description

    Endocrine disrupting agent
  • Biological description

    Endocrine disrupting agent. Induces estrogen receptor downregulation. Increases caspase-3/9, and Bax expression. Induces early p38 MAPK activation and translocation of ADAM17 to the cell surface. Induces germ cell apoptosis. Shows estrogenic effects in vivo.
  • CAS Number

    80-05-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[2-(4-Hydroxyphenyl)propan-2-yl]phenol
  • Molecular weight

    228.29
  • Molecular formula

    C15H16O2
  • PubChem identifier

    6623
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ahmed RA  et al. Effect of prenatal exposure to bisphenol a on the vagina of albino rats: immunohistochemical and ultrastructural study. Folia Morphol (Warsz) 73:399-408 (2014). Read more (PubMed: 25448896) »
  • Wang P  et al. Mitochondrion-mediated apoptosis is involved in reproductive damage caused by BPA in male rats. Environ Toxicol Pharmacol 38:1025-33 (2014). Read more (PubMed: 25461564) »
  • Urriola-Muñoz P  et al. A Mechanism of Male Germ Cell Apoptosis Induced by Bisphenol-A and Nonylphenol Involving ADAM17 and p38 MAPK Activation. PLoS One 9:e113793 (2014). Read more (PubMed: 25474107) »

Customer reviews and Q&As

Question
Answer


Bisphenol A is soluble in DMSO (˜ 3 mg/mL) and Methanol (˜ 3 mg/mL)

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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