Key features and details
- Potent G9a and G9a-like protein histone methyltransferase inhibitor
- CAS Number: 935693-62-2
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameBIX 01294, histone methyltransferase inhibitor
DescriptionPotent G9a and G9a-like protein histone methyltransferase inhibitor
Biological descriptionPotent, selective G9a and G9a-like protein histone lysine methyltransferase inhibitor (IC50 values are 1.7 and 0.7 μM at G9a and G9a-like protein, respectively). No activity at other HMT up to 37 μM. Antimalarial agent. Active in vitro.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141407 has been referenced in 1 publication.
- Kim SK et al. The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer. Int J Oncol 54:65-76 (2019). PubMed: 30365075