Overview

  • Product name

    BIX 01294, histone methyltransferase inhibitor
  • Description

    Potent G9a and G9a-like protein histone methyltransferase inhibitor
  • Biological description

    Potent, selective G9a and G9a-like protein histone lysine methyltransferase inhibitor (IC50 values are 1.7 and 0.7 μM at G9a and G9a-like protein, respectively). No activity at other HMT up to 37 μM. Antimalarial agent. Active in vitro.
  • Purity

    > 95%
  • CAS Number

    935693-62-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Schor IE  et al. Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation. EMBO J 32:2264-74 (2013). Read more (PubMed: 23892457) »
  • Malmquist NA  et al. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A 109:16708-13 (2012). Read more (PubMed: 23011794) »
  • Kubicek S  et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25:473-81 (2007). Read more (PubMed: 17289593) »

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