Blasticidin S hydrochloride (aqueous solution in HEPES, pH 7.5, sterile-filtered), antibiotic agent (ab146609)

Overview

  • Product name

    Blasticidin S hydrochloride (aqueous solution in HEPES, pH 7.5, sterile-filtered), antibiotic agent
  • Description

    Broad spectrum amino nucleoside antibiotic agent
  • Biological description

    Broad spectrum amino nucleoside antibiotic agent similar to puromycin (ab141841). Inhibits protein biosynthesis at both prokaryotic and eukaryotic ribosomes.

    Also available as a solid (ab141452).
  • Purity

    > 98%
  • CAS Number

    3513-03-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-1-(4-[[(3S)-3-amino-5-(N-methylcarbamimidamido)pentanoyl]amino]-2,3,4-trideoxy-β-D-erythro-hex-2-enopyranuronosyl)-2(1H)-pyrimidinone hydrochloride
  • Molecular weight

    458.90
  • Molecular formula

    C17H26N8O5.HCl
  • PubChem identifier

    25078183
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in 20 mM aqueous HEPES, pH 7.5 (10 mg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(CC[C@H](CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nishimura M  et al. Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis. J Biosci Bioeng 101:63-9 (2006). Read more (PubMed: 16503293) »
  • Kojima N  et al. Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells. J Biol Chem 269:30451-6 (1994). Read more (PubMed: 7982960) »
  • Swaminathan V  et al. Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate. Biochim Biophys Acta 655:335-41 (1981). Read more (PubMed: 7284390) »
See 1 Publication for this product

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