Bleomycin sulfate, anticancer and antibiotic agent (ab142977)

Overview

  • Product name
    Bleomycin sulfate, anticancer and antibiotic agent
  • Description
    Radiomimetic anticancer and antibiotic agent
  • Biological description
    Radiomimetic anticancer and antibiotic agent. Induces oxidative stress and DNA damage via single strand breaks, double strand breaks and apurinic/apyrimidinic modifications. Shows anticancer effects in vivo.
  • General notes

    This product is a mixture of glycopeptide antibiotics predominantly consisting of bleomycin A2 (~70%) and bleomycin B2 (~30%)

  • CAS Number
    9041-93-4
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Zhou CF  et al. Bleomycin-induced epithelial-mesenchymal transition in sclerotic skin of mice: possible role of oxidative stress in the pathogenesis. Toxicol Appl Pharmacol 277:250-8 (2014). Read more (PubMed: 24726524) »
  • Castore R  et al. Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis 26:795-803 (2011). Read more (PubMed: 21811007) »
  • Povirk LF & Houlgrave CW Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation and cleavage of closely opposed lesions in complementary strands. Biochemistry 27:3850-7 (1988). Read more (PubMed: 2457392) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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