Blonanserin, 5-HT2A, D2 and D3 receptor antagonist (ab145691)

Overview

  • Product name

    Blonanserin, 5-HT2A, D2 and D3 receptor antagonist
  • Description

    Potent, selective 5-HT2A, D2 and D3 receptor antagonist
  • Biological description

    Potent, selective 5-HT2A, D2 and D3 receptor antagonist (Ki values are 0.8, 26, 0.1, 0.5, 1070, 150 and 2600 nM for 5-HT2A, 5-HT2C, D2, D3, D1, D4 and D5 respectively). Shows antipsychotic effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    132810-10-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Hida H  et al. Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D3-5-HT2A and D1-NMDA receptors in the mPFC. Neuropsychopharmacology 40:601-13 (2015). Read more (PubMed: 25120077) »
  • Baba S  et al. The serotonin 5-HT1A receptor agonist tandospirone improves executive function in common marmosets. Behav Brain Res 287:120-6 (2015). Read more (PubMed: 25804359) »
  • Baba S  et al. Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range. J Pharmacol Sci 127:326-31 (2015). Read more (PubMed: 25837930) »

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