Anti-Blood Group A Antigen antibody [9A] (ab20131)
Key features and details
- Mouse monoclonal [9A] to Blood Group A Antigen
- Reacts with: Human
- Isotype: IgG3
Overview
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Product name
Anti-Blood Group A Antigen antibody [9A]
See all Blood Group A Antigen primary antibodies -
Description
Mouse monoclonal [9A] to Blood Group A Antigen -
Host species
Mouse -
Specificity
ab20131 cross reacts with EGF receptor in A431 cells only due to glycosylation defects in these cells which reveals otherwise cryptic sugar structures. -
Species reactivity
Reacts with: Human -
Immunogen
Cell preparation: A431 cells (human vulval squamous carcinoma cell line).
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
9A -
Myeloma
P3-x63-Ag8 -
Isotype
IgG3 -
Light chain type
unknown -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
-
Relevance
Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. -
Cellular localization
Cell Membrane -
Database links
- Entrez Gene: 28 Human
Datasheets and documents
References (3)
ab20131 has been referenced in 3 publications.
- Fischer MB et al. Surface Plasmon Resonance Analysis Shows an IgG-Isotype-Specific Defect in ABO Blood Group Antibody Formation in Patients with Common Variable Immunodeficiency. Front Immunol 6:211 (2015). PubMed: 25999949
- Gullick WJ & Lemoine NR 'EGF receptor' antibody 29.1.1. J Pathol 162:275-6 (1990). PubMed: 2266467
- Parker PJ et al. Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor. J Biol Chem 259:9906-12 (1984). PubMed: 6086658