Key features and details
- Mouse monoclonal [BFL 103] to Blooms Syndrome Protein Blm (FITC)
- Suitable for: ICC/IF
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Product nameAnti-Blooms Syndrome Protein Blm antibody [BFL 103] (FITC)
See all Blooms Syndrome Protein Blm primary antibodies
DescriptionMouse monoclonal [BFL 103] to Blooms Syndrome Protein Blm (FITC)
ConjugationFITC. Ex: 493nm, Em: 528nm
Specificityab187811 recognizes an epitope within the N-terminal domain (residues 1-447) of Blooms Syndrome Protein Blm.
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human Blooms Syndrome Protein Blm aa 1-1417.
Database link: P54132
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Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Purification notesab187811 is purified from tissue culture supernatant.
Clone numberBFL 103
Our Abpromise guarantee covers the use of ab187811 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration.|
FunctionParticipates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
Involvement in diseaseDefects in BLM are the cause of Bloom syndrome (BLM) [MIM:210900]. BLM is an autosomal recessive disorder characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability.
Sequence similaritiesBelongs to the helicase family. RecQ subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 HRDC domain.
modificationsPhosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1.
- Information by UniProt
- Blm antibody
- BLM_HUMAN antibody
- Bloom syndrome antibody
ab187811 has not yet been referenced specifically in any publications.