BMH 21, RNA polymerase I inhibitor (ab219384)

Overview

  • Product name

    BMH 21, RNA polymerase I inhibitor
  • Description

    RNA polymerase I inhibitor
  • Alternative names

    • BMH-21
    • BMH21
  • Biological description

    Potent, small molecule DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. Also acts as a p53 pathway activator; induces expression of p53 target genes. Antitumorigenic activity against a broad range of cancer cell lines and represses tumor growth in vivo.

  • Purity

    > 99%
  • CAS Number

    896705-16-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
  • Molecular weight

    360.41
  • Molecular formula

    C21H20N4O2
  • PubChem identifier

    3508054
  • Storage instructions

    Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CCNC(=O)C1=CC=CN2C1=NC3=CC4=CC=CC=C4C=C3C2=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Peltonen K  et al. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 25:77-90 (2014). Read more (PubMed: 24434211) »
  • Colis L  et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem 57:4950-61 (2014). Read more (PubMed: 24847734) »
  • Colis L  et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget 5:4361-9 (2014). Read more (PubMed: 24952786) »
  • Peltonen K  et al. Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS One 5:e12996 (2010). Read more (PubMed: 20885994) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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