Anti-Bmi1 antibody [F6] - ChIP Grade (ab14389)

Knockout Tested Mouse monoclonal Bmi1 antibody [F6]. Validated in WB, IP, IHC, ICC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Rabbit, Cat, Human, Xenopus laevis, Zebrafish.

Publishing research using ab14389? Please let us know so that we can cite the reference in this datasheet.

ab14389 has been referenced in 56 publications.

  • Zheng Q  et al. IL-17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K/AKT signalling pathway. J Cell Mol Med 23:357-369 (2019). PubMed: 30353649
  • Chow HY  et al. Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nat Commun 9:3473 (2018). PubMed: 30150766
  • Sun ZJ  et al. A fusion protein composed of the DSL domain of Dll1 and RGD motif protects cryptic stem cells in irradiation injury. Biosci Rep 38:N/A (2018). PubMed: 29444821
  • Zhang Y  et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature 548:52-57 (2017). PubMed: 28746310
  • Khan I  et al. Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines. Cancer Cell Int 17:72 (2017). PubMed: 28736504
  • Li H  et al. FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging. J Clin Invest 127:1241-1253 (2017). WB . PubMed: 28240601
  • Toth Z  et al. LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. PLoS Pathog 12:e1005878 (2016). Human . PubMed: 27606464
  • Shan ZN  et al. miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3. Oncotarget 7:78813-78826 (2016). Flow Cyt ; Human . PubMed: 27705931
  • Grun D  et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene 35:4379-87 (2016). PubMed: 26804163
  • Srinivasan T  et al. NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. Cancer Res 76:3411-21 (2016). PubMed: 27197180
  • Spadaro PA  et al. Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice. Biol Psychiatry 78:848-59 (2015). ChIP . PubMed: 25792222
  • Englert NA  et al. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem 290:2264-78 (2015). PubMed: 25391650
  • Liu K  et al. Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma. Int J Mol Med 36:783-91 (2015). PubMed: 26202447
  • Li J  et al. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell 33:125-35 (2015). Mouse . PubMed: 25865348
  • Adhikary G  et al. Survival of skin cancer stem cells requires the Ezh2 polycomb group protein. Carcinogenesis 36:800-10 (2015). PubMed: 25969142
  • Balasubramanian S  et al. The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (-) epigallocatechin-3-gallate suppression of skin cancer cell survival. Cell Signal 27:1336-44 (2015). PubMed: 25843776
  • López-Arribillaga E  et al. Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch. Development 142:41-50 (2015). IHC-P ; Mouse . PubMed: 25480918
  • Zheng S  et al. Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. J Immunol 195:217-26 (2015). ChIP ; Human . PubMed: 26019273
  • Hai B  et al. Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation. Clin Cancer Res 20:140-50 (2014). PubMed: 24150232
  • Dalley AJ  et al. Expression of ABCG2 and Bmi-1 in oral potentially malignant lesions and oral squamous cell carcinoma. Cancer Med 3:273-83 (2014). IHC-P ; Human . PubMed: 24415717
  • Benard A  et al. Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer. PLoS One 9:e108265 (2014). WB, IHC-P ; Human . PubMed: 25243792
  • Shen H  et al. BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. J Cell Mol Med 18:1004-17 (2014). ChIP . PubMed: 24571310
  • Bhatnagar S  et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature 516:116-20 (2014). ChIP . PubMed: 25470042
  • Martin N  et al. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation. EMBO J 32:982-95 (2013). PubMed: 23455154
  • Li HY  et al. The Xenopus homologue of Down syndrome critical region protein 6 drives dorsoanterior gene expression and embryonic axis formation by antagonising polycomb group proteins. Development 140:4903-13 (2013). Xenopus laevis . PubMed: 24301465
  • Cliffe AR  et al. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. MBio 4:N/A (2013). ChIP . PubMed: 23322639
  • Adhikary G  et al. Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. PLoS One 8:e84324 (2013). Human . PubMed: 24376802
  • Balasubramanian S  et al. A Proteasome Inhibitor-stimulated Nrf1 Protein-dependent Compensatory Increase in Proteasome Subunit Gene Expression Reduces Polycomb Group Protein Level. J Biol Chem 287:36179-89 (2012). WB . PubMed: 22932898
  • Völkel P  et al. A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription. Epigenetics 7:482-91 (2012). PubMed: 22419124
  • Mochida GH  et al. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet 44:1260-4 (2012). ChIP, ICC/IF ; Mouse, Human . PubMed: 23023333
  • Abdel-Wahab O  et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 22:180-93 (2012). PubMed: 22897849
  • Muñoz J  et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J 31:3079-91 (2012). PubMed: 22692129
  • Liu W  et al. Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study. Cancer 118:1693-700 (2012). PubMed: 22009787
  • García-Escudero V  et al. A neuroregenerative human ensheathing glia cell line with conditional rapid growth. Cell Transplant 20:153-66 (2011). PubMed: 20719080
  • Finnberg NK  et al. High-resolution imaging and antitumor effects of GFP(+) bone marrow-derived cells homing to syngeneic mouse colon tumors. Am J Pathol 179:2169-76 (2011). PubMed: 21975022
  • Kim HG  et al. Gene silencing in HIV-1 latency by polycomb repressive group. Virol J 8:179 (2011). IP ; Human . PubMed: 21496352
  • Choudhury SR  et al. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 32:1525-32 (2011). PubMed: 21798853
  • Häyry V  et al. Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue. Br J Cancer : (2010). IHC-P ; Human . PubMed: 20145620
  • Argiropoulos B  et al. Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. Blood 115:4071-82 (2010). ChIP ; Mouse . PubMed: 20237320
  • Chatoo W  et al. Bmi1 distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development. Stem Cells 28:1412-23 (2010). Flow Cyt ; Mouse . PubMed: 20549707
  • Iliopoulos D  et al. Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells. Mol Cell 39:761-72 (2010). WB ; Human . PubMed: 20832727
  • Balasubramanian S  et al. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis 31:496-503 (2010). WB ; Human . PubMed: 20015867
  • Kheradmand Kia S  et al. EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence. Epigenetics Chromatin 2:16 (2009). WB, ChIP ; Human . PubMed: 19954516
  • Ganguli-Indra G  et al. CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS ONE 4:e5367 (2009). IHC-P ; Human . PubMed: 19399189
  • Boukarabila H  et al. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev 23:1195-206 (2009). ChIP ; Human . PubMed: 19451220
  • Chan KS  et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A 106:14016-21 (2009). IHC-P ; Human . PubMed: 19666525
  • Maertens GN  et al. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One 4:e6380 (2009). WB ; Human . PubMed: 19636380
  • Yue R  et al. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 139:535-46 (2009). ChIP ; Zebrafish . PubMed: 19879840
  • Kia SK  et al. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol 28:3457-64 (2008). WB, ChIP ; Human . PubMed: 18332116
  • Kerosuo L  et al. Myc increases self-renewal in neural progenitor cells through Miz-1. J Cell Sci 121:3941-50 (2008). ICC/IF, Flow Cyt ; Mouse . PubMed: 19001505
  • Häyry V  et al. Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours. Neuropathol Appl Neurobiol 34:555-63 (2008). PubMed: 18346113
  • Lee K  et al. Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol 128:9-17 (2008). PubMed: 17625597
  • Gazin C  et al. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449:1073-7 (2007). PubMed: 17960246
  • Leeb M & Wutz A Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells. J Cell Biol 178:219-29 (2007). WB ; Mouse . PubMed: 17620408
  • Prince ME  et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 104:973-8 (2007). IHC-Fr ; Human . PubMed: 17210912
  • Sasaki M  et al. Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis. Am J Pathol 169:831-45 (2006). PubMed: 16936260

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