Overview

  • Product name

    BML-278, SIRT activator
  • Description

    Potent, cell-permeable SIRT activator
  • Biological description

    Potent, cell-permeable SIRT activator. Shows selectivity for SIRT1. Induces cell cycle arrest at G1/S phase.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
  • Molecular weight

    391.47
  • Molecular formula

    C24H25NO4
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(OCC)C2=CN(Cc1ccccc1)C=C(C2c3ccccc3)C(=O)OCC
  • Source

    Synthetic

References

This product has been referenced in:

  • Mai A  et al. Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J Med Chem 52:5496-504 (2009). Read more (PubMed: 19663498) »
See 1 Publication for this product

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