Overview

  • Product name
    BML 283, Tumor M2-PK activator
  • Description
    Potent, selective tumor cell specific Tumor M2-PK activator
  • Biological description
    Potent, selective tumor cell specific Tumor M2-PK activator (EC50 = 111 nM).
  • Purity
    > 98%
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)piperazine
  • Molecular weight
    454.50
  • Molecular formula
    C19H22N2O7S2
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COc1ccc(cc1)S(=O)(=O)N2CCN(CC2)S(=O)(=O)c3ccc4OCCOc4c3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Boxer MB  et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem 53:1048-55 (2010). Read more (PubMed: 20017496) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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