Overview

  • Product name

    BML 284, Wnt signaling activator
  • Description

    Cell-permeable Wnt signaling activator
  • Biological description

    Cell-permeable Wnt signaling activator. Induces β-catenin and TCF-dependent transcriptional activity (EC50 = 0.7 μM). Activates Wnt without inhibiting GSK-3β.Shows developmental effects in vivo.
  • Purity

    > 98%
  • CAS Number

    853220-52-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-N-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine
  • Molecular weight

    350.40
  • Molecular formula

    C19H18N4O3
  • PubChem identifier

    11210285
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li S  et al. Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo. Differentiation 76:897-907 (2008). Read more (PubMed: 18452549) »
  • Liu J  et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl 44:1987-90 (2005). Read more (PubMed: 15724259) »
  • Gazit A  et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18:5959-66 (1999). Read more (PubMed: 10557084) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145241.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up