Anti-BMP1/PCP antibody (ab38953)
Key features and details
- Rabbit polyclonal to BMP1/PCP
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-BMP1/PCP antibody
See all BMP1/PCP primary antibodies -
Description
Rabbit polyclonal to BMP1/PCP -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human BMP1/PCP (C terminal).
(Peptide available asab41291) -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituent: 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab38953 has been peptide-affinity purified. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab38953 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 111 kDa.
A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. |
Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 111 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. |
Target
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Function
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. -
Tissue specificity
Ubiquitous. -
Involvement in disease
Osteogenesis imperfecta 13 -
Sequence similarities
Belongs to the peptidase M12A family.
Contains 5 CUB domains.
Contains 2 EGF-like domains. -
Post-translational
modificationsProteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. -
Cellular localization
Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Co-localizes with POSTN in the Golgi. - Information by UniProt
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Database links
- Entrez Gene: 649 Human
- Entrez Gene: 12153 Mouse
- Omim: 112264 Human
- SwissProt: P13497 Human
- SwissProt: P98063 Mouse
- Unigene: 1274 Human
- Unigene: 27757 Mouse
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Alternative names
- BMP 1 antibody
- BMP-1 antibody
- BMP1 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab38953 has been referenced in 5 publications.
- Kazakevych J et al. Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium. Genome Biol 21:64 (2020). PubMed: 32160911
- Jameson SA et al. Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase-like 1 knockout mouse model. Physiol Rep 8:e14436 (2020). PubMed: 32533648
- Voorhees AP et al. Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction. J Mol Cell Cardiol 85:229-39 (2015). PubMed: 26080361
- Zamilpa R et al. CC chemokine receptor 5 deletion impairs macrophage activation and induces adverse remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol 300:H1418-26 (2011). WB ; Mouse . PubMed: 21297029
- Ahn Y et al. Mining of serum glycoproteins by an indirect approach using cell line secretome. Mol Cells 29:123-30 (2010). WB ; Human . PubMed: 20016938