Overview

  • Product name
  • Description
    Rabbit polyclonal to BMP15
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human BMP15 aa 249-278 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: O95972

  • Positive control
    • CEM cell lysate; Human prostate carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab173886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 45 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
  • Involvement in disease
    Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
    Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BMP 15 antibody
    • BMP-15 antibody
    • BMP15 antibody
    • BMP15_HUMAN antibody
    • Bone morphogenetic protein 15 antibody
    • GDF 9B antibody
    • GDF-9B antibody
    • GDF9B antibody
    • Growth/differentiation factor 9B antibody
    • ODG2 antibody
    • POF4 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human prostate carcinoma tissue labeling BMP15 using ab173886 at 1/50 dilution followed by peroxidase conjugation of the secondary antibody and DAB staining.

  • Anti-BMP15 antibody (ab173886) at 1/50 dilution + CEM cell lysate at 35 µg

    Predicted band size: 45 kDa

References

ab173886 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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