Overview

  • Product name

  • Description

    Rabbit polyclonal to BMP15
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human BMP15 (internal sequence). (BC117264. The identity of the protein fusion partner is GST).
    Database link: O95972

  • Positive control

    • A549 cell lysate; Human thyroid cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 45 kDa.

Target

  • Function

    May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
  • Involvement in disease

    Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
    Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
  • Sequence similarities

    Belongs to the TGF-beta family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • BMP 15 antibody
    • BMP-15 antibody
    • BMP15 antibody
    • BMP15_HUMAN antibody
    • Bone morphogenetic protein 15 antibody
    • GDF 9B antibody
    • GDF-9B antibody
    • GDF9B antibody
    • Growth/differentiation factor 9B antibody
    • ODG2 antibody
    • POF4 antibody
    see all

Images

  • Anti-BMP15 antibody (ab198226) at 1/267 dilution + A549 cell lysate at 60 µg

    Predicted band size: 45 kDa


    Exposure time: 5 minutes


    10% SDS-PAGE.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling BMP15 with ab198226 at 1/40 dilution.

References

This product has been referenced in:

  • Besikcioglu HE  et al. Determination of the effects of bone marrow derived mesenchymal stem cells and ovarian stromal stem cells on follicular maturation in cyclophosphamide induced ovarian failure in rats. Taiwan J Obstet Gynecol 58:53-59 (2019). Read more (PubMed: 30638481) »
See 1 Publication for this product

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