Overview

  • Product name

  • Description

    Goat polyclonal to BMP1/PCP
  • Host species

    Goat
  • Specificity

    ab205394 is expected to recognize both reported isoforms (NP_001190.1; NP_006120.1).
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to Human BMP1/PCP aa 284-296 (internal sequence) (Cysteine residue). NP_001190.1; NP_006120.1.
    Sequence:

    DTIVPKYEVNGVK


    Database link: P13497

  • Positive control

    • WB: Human heart, human kidney and rat heart tissue lysates and NIH3T3 cell lysate.
  • General notes

    Protein previously labeled as BMP1.

Properties

Applications

Our Abpromise guarantee covers the use of ab205394 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 111 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
  • Tissue specificity

    Ubiquitous.
  • Involvement in disease

    Osteogenesis imperfecta 13
  • Sequence similarities

    Belongs to the peptidase M12A family.
    Contains 5 CUB domains.
    Contains 2 EGF-like domains.
  • Post-translational
    modifications

    Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
  • Cellular localization

    Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Co-localizes with POSTN in the Golgi.
  • Information by UniProt
  • Database links

  • Alternative names

    • BMP 1 antibody
    • BMP-1 antibody
    • BMP1 antibody
    • BMP1_HUMAN antibody
    • Bone morphogenetic protein 1 antibody
    • Mammalian tolloid protein antibody
    • mTld antibody
    • OI13 antibody
    • PCOLC antibody
    • PCP antibody
    • PCP2 antibody
    • Procollagen C endopeptidase antibody
    • Procollagen C proteinase antibody
    • Procollagen C-proteinase antibody
    • TLD antibody
    • Tolloid, Drosophila, homolog of antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human placenta tissue, staining BMP1/PCP with ab205394 at 5µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

  • Anti-BMP1/PCP antibody (ab205394) at 2 µg/ml + NIH3T3 cell lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 111 kDa



    Incubated with the primary antibody for 1 hour.

  • Anti-BMP1/PCP antibody (ab205394) at 2 µg/ml + Rat heart tissue lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 111 kDa



    Incubated with the primary antibody for 1 hour.

  • All lanes : Anti-BMP1/PCP antibody (ab205394) at 1 µg/ml

    Lane 1 : Human heart cell lysate
    Lane 2 : Human kidney cell lysate

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 111 kDa

References

ab205394 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab205394.
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