BMS 345541, IKK-2 and IKK-1 inhibitor (ab144822)
Key features and details
- Highly selective cell permeable IKK-2 and IKK-1 inhibitor
- CAS Number: 445430-58-0
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMS 345541, IKK-2 and IKK-1 inhibitor -
Description
Highly selective cell permeable IKK-2 and IKK-1 inhibitor -
Biological description
Highly selective cell permeable IKK-2 and IKK-1 inhibitor (IC50 values are 0.3 and 4 μM for IKK-2 and IKK-1 respectively). Blocks NF-κB-dependent transcription. Shows anti-inflammatory and radiosensitizing effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
445430-58-0 -
Chemical structure
Properties
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Chemical name
N'-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
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Molecular weight
255.32 -
Molecular formula
C14H17N5 -
PubChem identifier
9813758 -
Storage instructions
Store at +4°C (desiccating conditions). -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (4)
ab144822 has been referenced in 4 publications.
- Cuaycal AE et al. Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature. Gut Microbes 15:2252447 (2023). PubMed: 37675983
- Mirzaei R et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NF?B pathway. Sci Adv 7:eabh2148 (2021). PubMed: 34739319
- Hahn A et al. Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. J Cachexia Sarcopenia Muscle 11:103-119 (2020). PubMed: 31441598
- Zhang Y et al. The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFc?RIIbhiRegulatory B-Cell Subset in Lupus. J Invest Dermatol 137:2532-2543 (2017). PubMed: 28844943