Overview

  • Product name

    BMS 345541, IKK-2 and IKK-1 inhibitor
  • Description

    Highly selective cell permeable IKK-2 and IKK-1 inhibitor
  • Biological description

    Highly selective cell permeable IKK-2 and IKK-1 inhibitor (IC50 values are 0.3 and 4 μM for IKK-2 and IKK-1 respectively). Blocks NF-κB-dependent transcription. Shows anti-inflammatory and radiosensitizing effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    547757-23-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Li J  et al. Effects of canonical NF-?B signaling pathway on the proliferation and odonto/osteogenic differentiation of human stem cells from apical papilla. Biomed Res Int 2014:319651 (2014). Read more (PubMed: 24864235) »
  • Wu L  et al. BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiat Res 179:160-70 (2013). Read more (PubMed: 23259762) »
  • Burke JR  et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278:1450-6 (2003). Read more (PubMed: 12403772) »
See 1 Publication for this product

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