Product nameBMS-599626 (AC480), HER1 and HER2 inhibitor
DescriptionSelective HER1 and HER2 inhibitor
Biological descriptionSelective HER1 and HER2 inhibitor (IC50 values are 20 and 30 nM respectively). Anticancer activity in vitro and in vivo. Orally active.
Chemical name[(3S)-Morpholin-3-yl]methyl-N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Torres MA et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs 29:554-61 (2011). Read more (PubMed: 20119866) »
- Haluska P et al. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther 7:2589-98 (2008). Read more (PubMed: 18765823) »
- Wong TW et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res 12:6186-93 (2006). Read more (PubMed: 17062696) »