Overview

  • Product name

    BMS-599626 (AC480), HER1 and HER2 inhibitor
  • Description

    Selective HER1 and HER2 inhibitor
  • Biological description

    Selective HER1 and HER2 inhibitor (IC50 values are 20 and 30 nM respectively). Anticancer activity in vitro and in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    8173837-23-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Torres MA  et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs 29:554-61 (2011). Read more (PubMed: 20119866) »
  • Haluska P  et al. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther 7:2589-98 (2008). Read more (PubMed: 18765823) »
  • Wong TW  et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res 12:6186-93 (2006). Read more (PubMed: 17062696) »

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