BMS-707035, HIV-I integrase (IN) inhibitor (ab231361)

Overview

  • Product name

    BMS-707035, HIV-I integrase (IN) inhibitor
  • Description

    Potent, specific, reversible HIV-I integrase (IN) inhibitor
  • Biological description

    Potent, specific, reversible, pyrimidine carboxamide HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity in vitro (IC50 = 15 nM). Binding of BMS-707035 and target DNA to IN are mutually exclusive events, since the inhibition of strand transfer catalysis by BMS-707035 is overcome by increasing amount of target DNA. BMS-707035 binding affinity to IN is also affected by the four terminal bases at the 5′ end of the pre-processed U5 long terminal repeat (LTR).

  • CAS Number

    729607-74-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(1,1-Dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxamide
  • Molecular weight

    410.42
  • Molecular formula

    C17H19FN4O5S
  • PubChem identifier

    54682040
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • SMILES

    CN1C(=O)C(=C(N=C1N2CCCCS2(=O)=O)C(=O)NCC3=CC=C(C=C3)F)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Langley DR  et al. The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors. Biochemistry 47:13481-8 (2008). Read more (PubMed: 18991395) »
  • Dicker IB  et al. Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors. J Biol Chem 282:31186-96 (2007). Read more (PubMed: 17715137) »

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