Overview

  • Product name

    BMS 753, RARalpha agonist
  • Description

    Potent, selective RARα agonist
  • Biological description

    Potent, selective retinoic acid receptor α agonist (Ki = 2 nM). Antitumor agent. Active in vitro.
  • Purity

    > 98%
  • CAS Number

    215307-86-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
  • Molecular weight

    351.40
  • Molecular formula

    C21H21NO4
  • PubChem identifier

    9884820
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)c1ccc(cc1)NC(=O)c2ccc3c(c2)C(C)(C)C(=O)C3(C)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Kirchmeyer M  et al. All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation. Arthritis Res Ther 10:R141 (2008). Read more (PubMed: 19068145) »
  • Idres N  et al. Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. Biochem Pharmacol 69:1595-601 (2005). Read more (PubMed: 15896339) »
  • Géhin M  et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol 6:519-29 (1999). Read more (PubMed: 10421757) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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