BMS202 (PD-1/PD-L1 inhibitor 2), small-molecule inhibitor (ab231311)

Overview

  • Product name

    BMS202 (PD-1/PD-L1 inhibitor 2), small-molecule inhibitor
  • Description

    A small-molecule PD-1/PD-L1 interaction inhibitor
  • Alternative names

    • BMS202
  • Biological description

    PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 18 nM. Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

  • Purity

    > 98%
  • CAS Number

    1675203-84-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[[2-Methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide

  • Molecular weight

    419.53
  • Molecular formula

    C25H29N3O3
  • PubChem identifier

    117951478
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    83 mg/mL (197.84 mM) in DMSO.

  • SMILES

    CC1=C(C=CC=C1COC2=NC(=C(C=C2)CNCCNC(=O)C)OC)C3=CC=CC=C3
  • Source

    Synthetic

References

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