BNTX maleate, delta1 opioid receptor antagonist (ab146142)

Overview

  • Product name

    BNTX maleate, delta1 opioid receptor antagonist
  • Description

    Selective δ1 opioid receptor antagonist
  • Biological description

    Selective δ1 opioid receptor antagonist. Inhibits neurogenic ion transport in porcine ileal mucosa. Increases the antinociceptive ED50 value of DPDPE (ab120675) in vivo.
  • Purity

    > 97%
  • CAS Number

    864461-31-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5α,7E)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-
    (phenylmethylene)morphinan-6-one maleate
  • Molecular weight

    545.59
  • Molecular formula

    C27H27NO4.C4H4O4
  • PubChem identifier

    71433927
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)/C=C\C(=O)O.O=C2C(=C\c1ccccc1)\C[C@@]7(O)[C@H]4Cc6ccc(O)c5O[C@@H]2[C@]7(CCN4CC3CC3)c56
  • Source

    Synthetic

References

This product has been referenced in:

  • Komatsu T  et al. Spinal ERK2 activation through d2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin. Peptides 54:131-9 (2014). Read more (PubMed: 24480726) »
  • Poonyachoti S  et al. Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic delta- and mu-opioid agonists on neurogenic ion transport in porcine ileal mucosa. J Pharmacol Exp Ther 297:672-9 (2001). Read more (PubMed: 11303057) »
  • Sofuoglu M  et al. 7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. Life Sci 52:769-75 (1993). Read more (PubMed: 8383271) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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