Boc-D-FMK, caspase inhibitor (ab142036)
Key features and details
- Irreversible general caspase inhibitor. Cell-permeable.
- CAS Number: 187389-53-3
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Boc-D-FMK, caspase inhibitor -
Description
Irreversible general caspase inhibitor. Cell-permeable. -
Biological description
Irreversible general caspase inhibitor. Blocks hepatocyte apoptosis in vivo. Active in vitro and in vivo. Cell-permeable.
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CAS Number
187389-53-3 -
Chemical structure
Properties
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Chemical name
Boc-Asp(OMe)-fluoromethyl ketone -
Molecular weight
263.26 -
Molecular formula
C11H18FNO5 -
PubChem identifier
16760348 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 20 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab142036 has been referenced in 2 publications.
- de León A et al. NGF-Dependent and BDNF-Dependent DRG Sensory Neurons Deploy Distinct Degenerative Signaling Mechanisms. eNeuro 8:N/A (2021). PubMed: 33372032
- Qiu X et al. CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells. Cell Death Dis 6:e1864 (2015). PubMed: 26313915