Anti-Bok antibody (ab2304)
- Datasheet
- References (1)
- Protocols
Overview
-
Product nameAnti-Bok antibody
See all Bok primary antibodies -
DescriptionRabbit polyclonal to Bok
-
Host speciesRabbit
-
SpecificityThe antibody detects the 18 kDa recombinant rat BOK expressed in E.coli.
-
Tested applicationsSuitable for: WBmore details
-
Species reactivityReacts with: Rat
-
Immunogen
Synthetic peptide: corresponding to amino acids 41-61 of Bok
-
General notes
Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
Properties
-
FormLiquid
-
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
-
Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: 50% Glycerol, 1% BSA, PBS, pH 7.2 -
Concentration information loading...
-
PurityImmunogen affinity purified
-
Primary antibody notesBok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
-
ClonalityPolyclonal
-
IsotypeIgG
-
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
Our Abpromise guarantee covers the use of ab2304 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | Use a concentration of 1 - 2 µg/ml. |
Target
-
FunctionMay play a role in apoptosis.
-
Tissue specificityExpressed in brain, liver, appendix and lymphoid tissues.
-
Sequence similaritiesBelongs to the Bcl-2 family.
- Information by UniProt
-
Database links
- Entrez Gene: 29884 Rat
- SwissProt: Q792S6 Rat
- Unigene: 44461 Rat
-
Alternative names
- Bcl 2 related ovarian killer protein antibody
- Bcl-2-like protein 9 antibody
- Bcl-2-related ovarian killer protein antibody
see all
Protocols
References
This product has been referenced in:
- Siu PM & Alway SE Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle. J Physiol 565:309-23 (2005). WB ; Rat . Read more (PubMed: 15774533) »