Overview

  • Product name

    Bongkrekic Acid, Triammonium Salt, MPTP inhibitor
  • Description

    MPTP inhibitor; apoptosis inhibitor
  • Biological description

    Mitochondrial permeability transition pore inhibitor. Ligand of adenine nucleotide translocator. Inhibits apoptosis. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    11076-19-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaenedioic acid triammonium salt
  • Molecular weight

    537.69
  • Molecular formula

    C28H38O7.3NH3
  • PubChem identifier

    6433556
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water at 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC=CCCC=CC=CCC(C(=CC=C(C)C(=O)O)C)OC)C=CC(=CC(=O)O)CC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Vanderluit JL  et al. In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. Cell Death Differ 10:969-76 (2003). Read more (PubMed: 12934071) »
  • Cao G  et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 21:321-33 (2001). Read more (PubMed: 11323518) »
  • Stoner CD & Sirak HD Adenine nucleotide-induced contraction on the inner mitochondrial membrane. II. Effect of bongkrekic acid. J Cell Biol 56:65-73 (1973). Read more (PubMed: 4345167) »
See 1 Publication for this product

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