Overview

  • Product name
    Borrelidin, threonyl-tRNA synthetase inhibitor
  • Description
    Potent antiangiogenic agent. Selective threonyl-tRNA synthetase inhibitor.
  • Biological description
    Potent antiangiogenic agent (IC50 = 0.8 nM, rat aorta). Selective threonyl-tRNA synthetase inhibitor. Antibiotic agent. CDK inhibitor. Induces apoptosis in capillary tube-forming endothelial cells. Disrupts capillary tubes and inhibits their formation. Shows antiviral and antifungal effects. Shows antiangiogenic effects in vivo.
  • Purity
    > 98%
  • CAS Number
    7184-60-3
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Gafiuc D  et al. Borrelidin has limited anti-cancer effects in bcl-2 overexpressing breast cancer and leukemia cells and reveals toxicity in non-malignant breast epithelial cells. J Appl Toxicol 34:1109-13 (2014). Read more (PubMed: 24155182) »
  • Gao YM  et al. Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae. J Agric Food Chem 60:9874-81 (2012). Read more (PubMed: 22967236) »
  • Olano C  et al. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol 11:87-97 (2004). Read more (PubMed: 15112998) »
See 1 Publication for this product

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