Bortezomib, proteasome inhibitor (ab142123)

Overview

  • Product name

    Bortezomib, proteasome inhibitor
  • Description

    Potent, selective, reversible proteasome inhibitor
  • Alternative names

    • MG-341
    • PS-341
    • Velcade
  • Biological description

    Potent, selective, reversible proteasome inhibitor (Ki = 0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. 

  • Purity

    > 98%
  • CAS Number

    179324-69-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
  • Molecular weight

    384.25
  • Molecular formula

    C19H25BN4O4
  • PubChem identifier

    387447
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 90 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Roccaro AM  et al. Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells. Cancer Res 66:184-91 (2006). Read more (PubMed: 16397231) »
  • Williams S  et al. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol Cancer Ther 2:835-43 (2003). Read more (PubMed: 14555702) »
  • Adams J  et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59:2615-22 (1999). Read more (PubMed: 10363983) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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