Key features and details
- Potent, selective, reversible proteasome inhibitor
- CAS Number: 179324-69-7
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 90 mM
- Form / State: Solid
- Source: Synthetic
Product nameBortezomib, proteasome inhibitor
DescriptionPotent, selective, reversible proteasome inhibitor
Potent, selective, reversible proteasome inhibitor (Ki = 0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
Chemical nameN-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 90 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142123 has been referenced in 1 publication.
- Gain C et al. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. PLoS Pathog 16:e1008105 (2020). PubMed: 32092124