Overview

  • Product name

    BQ-123, ETA receptor antagonist
  • Description

    Potent, selective ETA receptor antagonist
  • Biological description

    Potent, selective ETA receptor antagonist (IC50 values are 7.3 and 18,000 nM for ETA and ETB endothelin receptors respectively). Some ability to cross the blood-brain barrier. Anti-ischemic activity in vivo.
  • Purity

    > 95%
  • CAS Number

    136553-81-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Thorin E & Webb DJ Endothelium-derived endothelin-1. Pflugers Arch 459:951-8 (2010). Read more (PubMed: 19967386) »
  • Kitazawa T  et al. Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides. J Pharmacol Exp Ther 286:890-5 (1998). Read more (PubMed: 9694947) »
  • Ihara M  et al. In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor. J Cardiovasc Pharmacol 20 Suppl 12:S11-4 (1992). Read more (PubMed: 1282942) »
See 1 Publication for this product

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