BQ 788 sodium salt, ETB receptor antagonist (ab144504)

Overview

  • Product name

    BQ 788 sodium salt, ETB receptor antagonist
  • Description

    Highly potent, selective ETB receptor antagonist
  • Biological description

    Highly potent, selective ETB receptor antagonist (IC50 values are 1.2 and 1300 nM for ET-1 binding to ETB and ETA, respectively). Inhibits ET-1 induced vasoconstriction, bronchoconstriction and cell proliferation. Shows antitumor effects.
  • Purity

    > 98%
  • CAS Number

    156161-89-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
  • Molecular weight

    663.79
  • Molecular formula

    C34H50N5NaO7
  • PubChem identifier

    23693553
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 5 mM
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]3CCC[C@@H](C)N3C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@H](Cc2cn(C(C)=O)c1ccccc12)C(=O)N[C@H](CCCC)C(=O)O[Na]
  • Source

    Synthetic

References

This product has been referenced in:

  • Brosseau JP  et al. Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues. Peptides 26:1441-53 (2005). Read more (PubMed: 16042984) »
  • Dai X  et al. Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats. Hypertension 43:1048-54 (2004). Read more (PubMed: 15051669) »
  • Okada M & Nishikibe M BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev 20:53-66 (2002). Read more (PubMed: 12070534) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144504.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up