Overview

  • Product name

    Brassinin, Inducer of phase II enzymes
  • Description

    Inducer of phase II enzymes
  • Biological description

    Inducer of phase II enzymes. Moderate and competitive indoleamine 2,3-dioxygenase inhibitor (Ki = 98 μM). Shows chemopreventive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    105748-59-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Methyl N-(1H-indol-3-ylmethyl)carbamodithioate
  • Molecular weight

    236.36
  • Molecular formula

    C11H12N2S2
  • PubChem identifier

    3035211
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CSC(=S)NCC1=CNC2=CC=CC=C21
  • Source

    Brassica rapa

  • Research areas

References

This product has been referenced in:

  • Banerjee T  et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene 27:2851-7 (2008). Read more (PubMed: 18026137) »
  • Gaspari P  et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem 49:684-92 (2006). Read more (PubMed: 16420054) »
  • Mehta RG  et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis 16:399-404 (1995). Read more (PubMed: 7859373) »

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