Anti-BRCA1 antibody [MS110] (ab16780)

Mouse monoclonal BRCA1 antibody [MS110]. Validated in IP, IHC, Flow Cyt, ICC/IF and tested in Human. Cited in 36 publication(s). Independently reviewed in 13 review(s).

Publishing research using ab16780? Please let us know so that we can cite the reference in this datasheet.

ab16780 has been referenced in 36 publications.

  • Luo Y  et al. ß-catenin nuclear translocation induced by HIF-1a overexpression leads to the radioresistance of prostate cancer. Int J Oncol 52:1827-1840 (2018). PubMed: 29658569
  • Kim S  et al. Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death Differ N/A:N/A (2018). PubMed: 30006610
  • He X & Fan S hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1. Oncol Rep 39:977-984 (2018). PubMed: 29286157
  • Zhao W  et al. BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. Nature 550:360-365 (2017). WB . PubMed: 28976962
  • Zhang X  et al. Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines. Drugs R D 17:569-583 (2017). ICC/IF ; Human . PubMed: 28879638
  • Bourton EC  et al. The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1+/- lymphoblastoid cells. J Cancer 8:4048-4056 (2017). ICC/IF ; Human . PubMed: 29187880
  • Irani S & Bidari-Zerehpoush F BRCA1/2 Mutations in Salivary Pleomorphic Adenoma and Carcinoma-ex-Pleomorphic Adenoma. J Int Soc Prev Community Dent 7:S155-S162 (2017). PubMed: 29285471
  • Wang H  et al. CD44+/CD24-phenotype predicts a poor prognosis in triple-negative breast cancer. Oncol Lett 14:5890-5898 (2017). PubMed: 29113223
  • Tan X  et al. miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer. Oncotarget 7:293-307 (2016). IF . PubMed: 26588055
  • Wu L  et al. Aberrant promoter methylation of cancer-related genes in human breast cancer. Oncol Lett 12:5145-5155 (2016). PubMed: 28105221
  • Penterling C  et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS One 11:e0156599 (2016). IF . PubMed: 27253695
  • Zhao MJ  et al. Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy. Oncotarget 7:8956-67 (2016). IF . PubMed: 26788910
  • Onyango DO  et al. Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination. Nucleic Acids Res 44:5702-16 (2016). ICC/IF . PubMed: 27084940
  • Wilson FR  et al. Cdk-dependent phosphorylation regulates TRF1 recruitment to PML bodies and promotes C-circle production in ALT cells. J Cell Sci 129:2559-72 (2016). PubMed: 27185864
  • Takata K  et al. Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN). J Biol Chem 290:24278-93 (2015). WB ; Human . PubMed: 26269593
  • Boukerroucha M  et al. BRCA1 germline mutation and glioblastoma development: report of cases. BMC Cancer 15:181 (2015). PubMed: 25880076
  • Fan S  et al. Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis. Oncotarget 6:14885-904 (2015). WB, IHC, ChIP . PubMed: 25912308
  • Masuda Y  et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun 6:7299 (2015). Human . PubMed: 26095369
  • Zhu Q  et al. Autoimmune response to PARP and BRCA1/BRCA2 in cancer. Oncotarget 6:11575-84 (2015). IHC . PubMed: 25865228
  • Batenburg NL  et al. Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J 34:1399-416 (2015). PubMed: 25820262
  • Li L  et al. Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. Sci Signal 7:ra47 (2014). PubMed: 24847116
  • Muñoz MC  et al. An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells. Nucleic Acids Res 42:7720-33 (2014). WB . PubMed: 24829461
  • Wei JT  et al. Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China. Sci Rep 4:5360 (2014). PubMed: 24942640
  • Hill SJ  et al. BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol 34:3828-42 (2014). PubMed: 25092866
  • Kim HJ  et al. One Case of a BRCA1 Germ Line Mutation Ovarian Carcinoma Patient Based on Abnormal Immunohistochemistry Finding. Korean J Pathol 48:379-81 (2014). IHC ; Human . PubMed: 25366075
  • Birkenkamp-Demtröder K  et al. Keratin23 (KRT23) Knockdown Decreases Proliferation and Affects the DNA Damage Response of Colon Cancer Cells. PLoS One 8:e73593 (2013). WB ; Human . PubMed: 24039993
  • Almalki A  et al. Mutation of the human mitochondrial phenylalanine-tRNA synthetase causes infantile-onset epilepsy and cytochrome c oxidase deficiency. Biochim Biophys Acta 1842:56-64 (2013). Human . PubMed: 24161539
  • McKerlie M  et al. Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation. Nucleic Acids Res N/A:N/A (2013). Human . PubMed: 23997120
  • Wu L  et al. BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiat Res 179:160-70 (2013). PubMed: 23259762
  • Muñoz MC  et al. RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. J Biol Chem 287:40618-28 (2012). WB ; Human . PubMed: 23055523
  • Kaira K  et al. Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer. Anticancer Res 31:2763-71 (2011). IHC ; Human . PubMed: 21868518
  • Keimling M  et al. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB J : (2011). PubMed: 21778326
  • Chène P  et al. Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue. BMC Chem Biol 9:1 (2009). IP ; Human . PubMed: 19128485
  • Geoffroy-Siraudin C  et al. Meiotic abnormalities in patients bearing complete AZFc deletion of Y chromosome. Hum Reprod 22:1567-72 (2007). ICC/IF ; Human . PubMed: 17428878
  • Wilson CA  et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21:236-40 (1999). PubMed: 9988281
  • Scully R  et al. Location of BRCA1 in human breast and ovarian cancer cells. Science 272:123-6 (1996). PubMed: 8600523


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