BRD-7389, p90 ribosomal S6 kinase RSK inhibitor (ab146161)

Overview

  • Product name

    BRD-7389, p90 ribosomal S6 kinase RSK inhibitor
  • Description

    p90 ribosomal S6 kinase RSK inhibitor
  • Biological description

    p90 ribosomal S6 kinase RSK inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in pancreatic α-cells. Shows reprogramming effects in terminally differentiated cells.
  • CAS Number

    376382-11-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
  • Molecular weight

    366.41
  • Molecular formula

    C24H18N2O2
  • PubChem identifier

    24870634
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CCNC2=C3C4C(=NC2=O)C=CC=C4C(=O)C5=CC=CC=C53
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Choudhary A  et al. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. PLoS One 9:e95194 (2014). Read more (PubMed: 24759943) »
  • Park YS & Cho NJ EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem 370:191-8 (2012). Read more (PubMed: 22865467) »
  • Fomina-Yadlin D  et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A 107:15099-104 (2010). Read more (PubMed: 20696901) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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