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ab75898 has been referenced in 20 publications.

  • Sui S  et al. Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. Cell Death Dis 10:331 (2019). PubMed: 30988278
  • Wang C  et al. miR-204 enhances p27 mRNA stability by targeting Brd4 in head and neck squamous cell carcinoma. Oncol Lett 16:4179-4184 (2018). PubMed: 30250532
  • Wang Y  et al. Bromodomain-containing protein 4 is critical for the antiproliferative and pro-apoptotic effects of gambogic acid in anaplastic thyroid cancer. Int J Mol Med 42:161-170 (2018). PubMed: 29717765
  • Col E  et al. Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Sci Rep 7:5418 (2017). PubMed: 28710461
  • Boehm D & Ott M Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. Bio Protoc 7:N/A (2017). PubMed: 29082287
  • Vázquez R  et al. Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts. Int J Cancer 140:197-207 (2017). WB ; Human . PubMed: 27594045
  • Henssen A  et al. Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition. Clin Cancer Res 22:2470-81 (2016). PubMed: 26631615
  • Boi M  et al. Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes. Oncotarget 7:79637-79653 (2016). WB . PubMed: 27793034
  • Kagoya Y  et al. BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models. J Clin Invest 126:3479-94 (2016). PubMed: 27548527
  • Wang YH  et al. BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway. Oncol Lett 10:2227-2232 (2015). PubMed: 26622824
  • Baratta MG  et al. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proc Natl Acad Sci U S A 112:232-7 (2015). WB ; Human . PubMed: 25535366
  • Boi M  et al. The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs. Clin Cancer Res 21:1628-38 (2015). PubMed: 25623213
  • Sun Y  et al. BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4/TRAF6/NF-?B pathway. Exp Ther Med 10:2319-2324 (2015). WB . PubMed: 26668635
  • Knoechel B  et al. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet 46:364-70 (2014). WB ; Human . PubMed: 24584072
  • Liu P  et al. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. J Biol Chem 289:9918-25 (2014). WB ; Human . PubMed: 24515107
  • Hussong M  et al. The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis 5:e1195 (2014). Human . PubMed: 24763052
  • Dawson MA  et al. Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia. Leukemia 28:311-20 (2014). IF . PubMed: 24220271
  • Kuzmina A  et al. A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription. Retrovirology 11:51 (2014). WB . PubMed: 24985467
  • Puissant A  et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov 3:308-23 (2013). WB ; Human . PubMed: 23430699
  • Bartholomeeusen K  et al. Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein. J Biol Chem 287:36609-16 (2012). WB . PubMed: 22952229

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