Overview

  • Product name

  • Description

    Rabbit polyclonal to BRD7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Synthetic peptide within Mouse BRD7 aa 387-418 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: O88665

  • Positive control

    • Mouse lung tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab202324 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 74 kDa.

Target

  • Function

    Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
  • Sequence similarities

    Contains 1 bromo domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 75 kDa bromodomain protein antibody
    • BP75 antibody
    • BRD 7 antibody
    • BRD7 antibody
    • BRD7_HUMAN antibody
    • Bromodomain containing 7 antibody
    • bromodomain containing protein 7 antibody
    • Bromodomain-containing protein 7 antibody
    • CELTIX 1 antibody
    • CELTIX1 antibody
    • NAG4 antibody
    • Protein CELTIX-1 antibody
    see all

Images

  • Anti-BRD7 antibody (ab202324) at 1/1000 dilution + mouse lung tissue lysate at 35 µg

    Secondary
    Goat anti-rabbit IgG H&L(HRP) at 1/10000 dilution

    Predicted band size: 74 kDa

References

ab202324 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab202324.
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