Overview

  • Product name

  • Description

    Rabbit polyclonal to BRD8/p120
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human BRD8/p120 aa 340-410 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    V PMEAVGDPHT VTVSMDSSEI SMIINSIKEE CFRSGVAEAP VGSKAPSIDG KEELDLAEKM DIAVSYTGEE


    Database link: Q9H0E9

  • Positive control

    • Rat brain tissue
  • General notes

    Previously labelled as BRD8

Properties

Applications

Our Abpromise guarantee covers the use of ab217850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Relevance

    BRD8 / p120 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. It interacts with MYC and adenovirus E1A protein.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • BRD8 antibody
    • Bromodomain containing 8 antibody
    • p120 antibody
    • Skeletal muscle abundant protein antibody
    • Skeletal muscle abundant protein 2 antibody
    • SMAP antibody
    • SMAP2 antibody
    • Thyroid hormone receptor coactivating protein 120kDa antibody
    • Thyroid hormone receptor coactivating protein antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded, formalin fixed rat brain tissue labeling BRD8  / p120 using ab217850 at 1/200 dilution.  Followed by conjugation to the secondary antibody and DAB staining.

References

ab217850 has not yet been referenced specifically in any publications.

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