Key features and details
- Potent allosteric voltage-gated Na+ channel activator
- CAS Number: 85079-48-7
- Purity: > 95%
- Soluble in water and in ethanol
- Form / State: Solid
- Source: Ptychodiscus brevis
Product nameBrevetoxin 3 (PbTx-3), voltage-gated Na+ channel activator
DescriptionPotent allosteric voltage-gated Na+ channel activator
Biological descriptionPotent allosteric voltage-gated Na+ channel activator. Binds to site 5 of NaV channels. Inhibits Na+ channel inactivation, shifts the activation curve and increases the open-channel probability. Induces pulmonary inflammation in vivo. Orally active.
Chemical name42-Deoxo-42-hydroxybrevetoxin B
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water and in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab143470 has not yet been referenced specifically in any publications.