Brevetoxin 3 (PbTx-3), voltage-gated Na+ channel activator (ab143470)

Overview

  • Product name

    Brevetoxin 3 (PbTx-3), voltage-gated Na+ channel activator
  • Description

    Potent allosteric voltage-gated Na+ channel activator
  • Biological description

    Potent allosteric voltage-gated Na+ channel activator. Binds to site 5 of NaV channels. Inhibits Na+ channel inactivation, shifts the activation curve and increases the open-channel probability. Induces pulmonary inflammation in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    85079-48-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zaias J  et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep. Inhal Toxicol 23:205-11 (2011). Read more (PubMed: 21456953) »
  • Kulagina NV  et al. Detection of marine toxins, brevetoxin-3 and saxitoxin, in seawater using neuronal networks. Environ Sci Technol 40:578-83 (2006). Read more (PubMed: 16468405) »
  • Benson JM  et al. Placental transport of brevetoxin-3 in CD-1 mice. Toxicon 48:1018-26 (2006). Read more (PubMed: 17011606) »
  • Jeglitsch G  et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. J Pharmacol Exp Ther 284:516-25 (1998). Read more (PubMed: 9454792) »

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