Overview

  • Product name

  • Description

    Rabbit polyclonal to Brevican
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 539-588 (PTETLPTPRE RNLASPSPST LVEAREVGEA TGGPELSGVP RGESEETGSS) of Human Brevican (NP_940819).

  • Positive control

Properties

Applications

Our Abpromise guarantee covers the use of ab106615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 72 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Relevance

    Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C-terminal epitope EAMESE.
  • Cellular localization

    Isoform 1 is secreted, extracellular space, extracellular matrix; Isoform 2 is found on the membrane; Lipid-anchor, GPI-anchor.
  • Database links

  • Alternative names

    • BCAN antibody
    • BEHAB antibody
    • Brain enriched hyaluronan binding protein antibody
    • Brevican core protein antibody
    • Brevican core protein isoform 1 antibody
    • Brevican core protein isoform 2 antibody
    • Brevican proteoglycan antibody
    • Chondroitin sulfate proteoglycan 7 antibody
    • Chondroitin sulfate proteoglycan BEHAB antibody
    • CSPG7 antibody
    • MGC13038 antibody
    see all

Images

  • Anti-Brevican antibody (ab106615) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size: 72 kDa

References

ab106615 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab106615.
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