Overview

  • Product name

    Brilliant Blue G, noncompetitive P2X7 antagonist
  • Description

    Potent, noncompetitive P2X7 antagonist
  • Alternative names

    • Acid blue 90
    • Coomassie® Brilliant Blue G
  • Biological description

    Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.
  • CAS Number

    6104-58-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt
  • Molecular weight

    854.02
  • Molecular formula

    C47H48N3NaO7S2
  • PubChem identifier

    61363
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ryu JK & McLarnon JG Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport 19:1715-9 (2008). Read more (PubMed: 18852683) »
  • Michel AD  et al. Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol 151:103-14 (2007). Read more (PubMed: 17339830) »
  • Jiang LH  et al. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol 58:82-8 (2000). Read more (PubMed: 10860929) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120389.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up