Overview

  • Product name

    Brinzolamide, carbonic anhydrase II inhibitor
  • Description

    Potent, selective, non-competitive and reversible carbonic anhydrase II inhibitor
  • Biological description

    Potent, selective, non-competitive and reversible carbonic anhydrase II inhibitor (IC50 = 2 nM). Decreases aqueous humor secretion. Increases blood flow to the optic nerve. Lowers intraocular pressure in vivo.
  • Purity

    > 99%
  • CAS Number

    138890-62-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4R)-4-(Ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
  • Molecular weight

    383.51
  • Molecular formula

    C12H21N3O5S3
  • PubChem identifier

    68844
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    S1(N(C[C@@H](C2=C1SC(=C2)S(=O)(=O)N)NCC)CCCOC)(=O)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang Y  et al. Development of inclusion complex of brinzolamide with hydroxypropyl-ß-cyclodextrin. Carbohydr Polym 98:638-43 (2013). Read more (PubMed: 23987393) »
  • Cincinelli A  et al. Purification and inhibition studies with anions and sulfonamides of an a-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii. Bioorg Med Chem 19:1847-51 (2011). Read more (PubMed: 21377369) »
  • Liu C  et al. Knockdown of NBCe1 in vivo compromises the corneal endothelial pump. Invest Ophthalmol Vis Sci 51:5190-7 (2010). Read more (PubMed: 20445126) »

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