Overview

  • Product name

    Brivudine, pyrimidine nucleoside analog
  • Description

    Pyrimidine nucleoside analog. Antiviral agent.
  • Biological description

    Pyrimidine nucleoside analog. Antiviral agent (IC50 values are 76 nM and 1.4 μM for herpesvirus and HIV respectively). Blocks DNA polymerase. Binds to heat shock protein HSPB1 and inhibits interaction with its binding partners. Shows anticancer effects in vivo. Orally active.
  • CAS Number

    69304-47-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(2-Bromoethenyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • Molecular weight

    333.13
  • Molecular formula

    C11H13BrN2O5
  • PubChem identifier

    3183
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang NQ  et al. Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine. Asian Pac J Cancer Prev 13:2121-7 (2012). Read more (PubMed: 22901180) »
  • Shiota T  et al. Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay. Antiviral Res 91:142-9 (2011). Read more (PubMed: 21669227) »
  • Mateu CG  et al. Emergence of herpes simplex virus-1 syncytial variants with altered virulence for mice after selection with a natural carrageenan. Sex Transm Dis 38:555-61 (2011). Read more (PubMed: 22256337) »

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