Overview

  • Product name

    BRL-50481, Selective PDE7 inhibitor
  • Description

    Selective PDE7 inhibitor
  • Biological description

    Selective, competitive PDE7 inhibitor (IC50 values are 0.15 and 12.1 μm for PDE7A and PDE7B respectively). Active in vivo and in vitro. Potentiates the anti-inflammatory effect of PDE4 inhibitor rolipram (ab120031). Cell and blood-brain barrier permeable.
  • Purity

    > 98%
  • CAS Number

    433695-36-4
  • Chemical structure

    Chemical Structure

Properties

Associated products

References

This product has been referenced in:

  • Alaamery MA  et al. New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen 15:359-67 (2010). Read more (PubMed: 20228279) »
  • Jackson EK  et al. Characterization of renal ecto-phosphodiesterase. J Pharmacol Exp Ther 321:810-5 (2007). Read more (PubMed: 17308037) »
  • Fan Chung K Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 533:110-7 (2006). Read more (PubMed: 16458289) »
  • Smith SJ  et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 66:1679-89 (2004). Read more (PubMed: 15371556) »

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