Overview

  • Product name

    BRL 52537 hydrochloride, kappa-opioid agonist
  • Description

    Highly selective, potent κ-opioid agonist
  • Biological description

    Highly selective and potent κ-opioid agonist (Ki = 0.24 nM). 25 times more potent than morphine. Neuroprotective effects seen in vivo.
  • Purity

    > 99%
  • CAS Number

    112282-24-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Su X  et al. The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons. Anesth Analg 109:632-40 (2009). Read more (PubMed: 19608841) »
  • Chen TY  et al. Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats. Stroke 35:1180-5 (2004). Read more (PubMed: 15031456) »
  • Vecchietti V  et al. (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. J Med Chem 34:397-403 (1991). Read more (PubMed: 1846921) »

Customer reviews and Q&As

Answer

Thank you for contacting us.

Unfortunately as we do not currently undertake our own research we are only able to offer information that is currently available in the literature. It appears that BRL 52537 is used most commonly at 1mg/kg/h, given by intravenous infusion. One paper, by Zeynalov et al., 2006 used an infusion rate of 0.05 ml/h in a mouse model. I have attached this paper for your information.

There does not appear to be any information regarding the LD50.

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