Overview

  • Product name

    BRL 54443, agonist at 5-HT1E and 5-HT1F receptors
  • Description

    Selective agonist at 5-HT1E and 5-HT1F receptors
  • Biological description

    Potent, high affinity and selective agonist at 5-HT1E/1F receptors (pKi values are 8.7 and 8.9, respectively). Displays >30-fold selectivity for human 5-HT over dopamine receptors (pKi values are 7.2 (5-HT1A), 6.9 (5-HT1B), 7.2 (5-HT1D), 5.9 (5-HT2A), 7.0 (5-HT2B), 6.5 (5-HT2C), 6.3 (D2) and 6.2 (D3)).
  • Purity

    > 99%
  • CAS Number

    57477-39-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole
  • Molecular weight

    230.31
  • Molecular formula

    C14H18N2O
  • PubChem identifier

    2438
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCC(CC1)c2cnc3ccc(O)cc23
  • Source

    Synthetic

  • Research areas

References

ab120627 has not yet been referenced specifically in any publications.

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