Bromopyruvic acid (3-bromopyruvic acid), Hexokinase II inhibitor (ab146138)

Overview

  • Product name

    Bromopyruvic acid (3-bromopyruvic acid), Hexokinase II inhibitor
  • Description

    Hexokinase II inhibitor. Antiumor agent.
  • Alternative names

    • 3-bromopyruvic acid
  • Biological description

    Hexokinase II inhibitor. Antitumor agent. Inhibits glutathione S-transferase and SOD. Pyruvic acid (ab145036) derivative. Induces oxidative stress. Induces S and G2/M cell cycle arrest. Shows antiproliferative effects. Shows antitumor and antimicrobial effects in vivo.
  • CAS Number

    1113-59-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Bromo-2-oxopropanoic acid
  • Molecular weight

    166.96
  • Molecular formula

    C3H3BrO3
  • PubChem identifier

    70684
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(C(=O)C(=O)O)Br
  • Source

    Synthetic

References

This product has been referenced in:

  • Gong L  et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. Anticancer Agents Med Chem 14:771-6 (2014). Read more (PubMed: 24738957) »
  • Sadowska-Bartosz I & Bartosz G Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system. Cell Biol Int 37:1285-90 (2013). Read more (PubMed: 23881849) »
  • Liu XH  et al. Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction. Chin Med J (Engl) 122:1681-5 (2009). Read more (PubMed: 19719971) »

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