Overview

  • Product name

    Brucine, Positive allosteric modulator at M1 receptors
  • Description

    Positive allosteric modulator at M1 receptors
  • Biological description

    Positive allosteric modulator at M1 receptors. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.
  • Purity

    > 98%
  • CAS Number

    357-57-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Agrawal SS  et al. Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line. Life Sci 89:147-58 (2011). Read more (PubMed: 21684292) »
  • Deng X  et al. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. Toxicol Sci 91:59-69 (2006). Read more (PubMed: 16443926) »
  • Bradley KN  et al. Effects of brucine, a plant alkaloid, on M(1) muscarinic receptors and alpha(1)-adrenoceptors in the rabbit vas deferens preparation. Toxicon 39:581-7 (2001). Read more (PubMed: 11024498) »

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