Overview

  • Product name

    Bryostatin 1, protein kinase C activator
  • Description

    Potent protein kinase C activator
  • Biological description

    Potent protein kinase C activator with high binding affinity (Ki = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA (ab120297). Range of biological activities. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    83314-01-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    905.03
  • Molecular formula

    C47H68O17
  • PubChem identifier

    5280757
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O
  • Source

    Bugula neritina

  • Research areas

References

This product has been referenced in:

  • Sun MK & Alkon DL Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev 12:1-8 (2006). Read more (PubMed: 16834754) »
  • Gschwend JE  et al. Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha. Mol Pharmacol 57:1224-34 (2000). Read more (PubMed: 10825394) »
  • Szallasi Z  et al. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem 269:2118-24 (1994). Read more (PubMed: 8294465) »

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