Key features and details
- Rabbit polyclonal to BSCL2/Seipin
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-BSCL2/Seipin antibody
See all BSCL2/Seipin primary antibodies
DescriptionRabbit polyclonal to BSCL2/Seipin
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Monkey
Synthetic peptide corresponding to Human BSCL2/Seipin (internal sequence).
Database link: Q96G97
This product was previously labelled as BSCL2
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab181761 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200 - 1/5000. Predicted molecular weight: 44 kDa.|
|IHC-P||1/100 - 1/2000.|
Tissue specificityHighest expression in brain and testis.
Involvement in diseaseDefects in BSCL2 are the cause of congenital generalized lipodystrophy type 2 (CGL2) [MIM:269700]. Congenital generalized lipodystrophy is an autosomal recessive disorder characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Defects in BSCL2 are the cause of spastic paraplegia type 17 (SPG17) [MIM:270685]; also known as Silver spastic paraplegia syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG17 is characterized by prominent amyotrophy of the hand muscles, the presence of mild to severe pyramidal tract signs, and spastic paraplegia. SPG17 is a motor neuron disease overlapping with distal spinal muscular atrophy type 5.
Defects in BSCL2 are a cause of distal hereditary motor neuropathy type 5 (HMN5) [MIM:600794]; also known aS distal hereditary motor neuropathy type V (DSMAV). HMN5 is an autosomal dominant disorder characterized by degeneration of motor nerve fibers, predominantly in limb distal regions.
Sequence similaritiesBelongs to the seipin family.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- Bernardinelli Seip congenital lipodystrophy 2 antibody
- Bernardinelli Seip congenital lipodystrophy type 2 protein antibody
- Bernardinelli-Seip congenital lipodystrophy type 2 protein antibody
ab181761 has not yet been referenced specifically in any publications.