Overview

  • Product name

    Anti-BSCL2/Seipin antibody
    See all BSCL2/Seipin primary antibodies
  • Description

    Rabbit polyclonal to BSCL2/Seipin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Synthetic peptide corresponding to Human BSCL2/Seipin (internal sequence).
    Database link: Q96G97

  • General notes

     This product was previously labelled as BSCL2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab181761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/5000. Predicted molecular weight: 44 kDa.
IHC-P 1/100 - 1/2000.

Target

  • Tissue specificity

    Highest expression in brain and testis.
  • Involvement in disease

    Defects in BSCL2 are the cause of congenital generalized lipodystrophy type 2 (CGL2) [MIM:269700]. Congenital generalized lipodystrophy is an autosomal recessive disorder characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
    Defects in BSCL2 are the cause of spastic paraplegia type 17 (SPG17) [MIM:270685]; also known as Silver spastic paraplegia syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG17 is characterized by prominent amyotrophy of the hand muscles, the presence of mild to severe pyramidal tract signs, and spastic paraplegia. SPG17 is a motor neuron disease overlapping with distal spinal muscular atrophy type 5.
    Defects in BSCL2 are a cause of distal hereditary motor neuropathy type 5 (HMN5) [MIM:600794]; also known aS distal hereditary motor neuropathy type V (DSMAV). HMN5 is an autosomal dominant disorder characterized by degeneration of motor nerve fibers, predominantly in limb distal regions.
  • Sequence similarities

    Belongs to the seipin family.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bernardinelli Seip congenital lipodystrophy 2 antibody
    • Bernardinelli Seip congenital lipodystrophy type 2 protein antibody
    • Bernardinelli-Seip congenital lipodystrophy type 2 protein antibody
    • BSCL 2 antibody
    • BSCL2 antibody
    • BSCL2_HUMAN antibody
    • GNG3LG antibody
    • HMN 5 antibody
    • HMN5 antibody
    • MGC4694 antibody
    • Seipin antibody
    • Spastic paraplegia 17 (autosomal dominant) antibody
    • Spastic paraplegia 17 (Silver syndrome) antibody
    • Spastic paraplegia 17 antibody
    • Spastic paraplegia with amyotrophy of hands and feet (Silver syndrome) antibody
    • Spastic paraplegia with amyotrophy of hands and feet antibody
    • SPG 17 antibody
    • SPG17 antibody
    see all

References

ab181761 has not yet been referenced specifically in any publications.

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