• Product name

    Anti-BST2/Tetherin antibody
    See all BST2/Tetherin primary antibodies
  • Description

    Rabbit polyclonal to BST2/Tetherin
  • Host species

  • Tested applications

    Suitable for: Dot blot, ELISA, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human BST2/Tetherin.

  • Positive control

    • Rat neonatal brain.
  • General notes

     This product was previously labelled as BST2




Our Abpromise guarantee covers the use of ab14694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot 1/2000.
ELISA 1/2000.
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).


  • Function

    May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.
  • Tissue specificity

    Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
  • Sequence similarities

    Belongs to the tetherin family.
  • Domain

    The extracellular coiled coil domain is important for virus retention at the cell surface and prevention of virus spreading.
  • Post-translational

    Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.
  • Cellular localization

    Golgi apparatus > trans-Golgi network. Cell membrane. Cell membrane. Late endosome. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bone marrow stromal antigen 2 antibody
    • Bone marrow stromal cell antigen 2 antibody
    • Bone marrow stromal cell antigen antibody
    • BST 2 antibody
    • BST-2 antibody
    • BST2 antibody
    • BST2_HUMAN antibody
    • CD 317 antibody
    • CD317 antibody
    • CD317 antigen antibody
    • HM1.24 antigen antibody
    • NPC A 7 antibody
    • Tetherin antibody
    see all


This product has been referenced in:

  • Sithole N  et al. DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV. J Mol Biol 430:3111-3128 (2018). Read more (PubMed: 30131116) »
  • Nishitsuji H  et al. ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor ? Light Chain Enhancer of Activated B Cells (NF-?B) Activation by BST-2. J Biol Chem 291:4754-62 (2016). Read more (PubMed: 26694617) »
See all 5 Publications for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A


Thank you for your enquiry. I can confirm that this product, ab14694 recognizes both the precursor protein of around 21kDa and the post translationally modified form of higher molecular weights. I hope this information will be helpful. If there is anything else that I can help you with, please do not hesitate to contact me.

Read More


Thank you for your enquiry. Ab14694 cross-reacts with human and rat BST2, and cross-reacts weakly with mouse. Rat neonatal brain or human recombinant protein are recommended as positive controls. If you have any additional questions, please contact us again.

Read More


Thank you for your enquiry. To answer your question. Yes, the antibody does contain 0.001% sodium azide with other preservatives. The antibody stabilization buffer also contains stabilizing proteins beside IgGs. I hope this information helps. Please do not hesitate to contact me should you require further assistance.

Read More

For licensing inquiries, please contact partnerships@abcam.com

Sign up